Identification and analysis of ribosome-associated lncRNAs using ribosome profiling data.

ABSTRACT:

Background

Although the number of discovered long non-coding RNAs (lncRNAs) has increased dramatically, their biological roles have not been established. Many recent studies have used ribosome profiling data to assess the protein-coding capacity of lncRNAs. However, very little work has been done to identify ribosome-associated lncRNAs, here defined as lncRNAs interacting with ribosomes related to protein synthesis as well as other unclear biological functions.

Results

On average, 39.17% of expressed lncRNAs were observed to interact with ribosomes in human and 48.16% in mouse. We developed the ribosomal association index (RAI), which quantifies the evidence for ribosomal associability of lncRNAs over various tissues and cell types, to catalog 691 and 409 lncRNAs that are ro

SUBMITTER: Zeng C 

PROVIDER: S-EPMC5975437 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature