Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection.

ABSTRACT:

Background

Development of sepsis is a process with significant variation among individuals. The precise elements of this variation need to be defined. This study was designed to define the way in which comorbidities contribute to sepsis development.

Methods

Three thousand five hundred nine patients with acute pyelonephritis (AP), community-acquired pneumonia (CAP), intraabdominal infections (IAI) or primary bacteremia (BSI) and at least two signs of the systemic inflammatory response syndrome were analyzed. The study primary endpoint was to define how comorbidities as expressed in the Charlson's comorbidity index (CCI) and the underlying type of infection contribute to development of organ dysfunction. The precise comorbidities that mediate sepsis development and risk for de

SUBMITTER: Sinapidis D 

PROVIDER: S-EPMC5975439 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature