ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL.

ABSTRACT:

Background

Glioma is the most common primary brain tumor in adults with a poor prognosis. As a member of ARF subfamily GTPase, ARL2 plays a key role in regulating the dynamics of microtubules and mitochondrial functions. Recently, ARL2 has been identified as a prognostic and therapeutic target in a variety range of malignant tumors. However, the biological functional role of ARL2 in glioma still remains unknown. The aim of this study was to explore the expression and functional role of ARL2 in glioma.

Methods

In this study, we investigated the expression of ARL2 in glioma samples by using RT-PCR, immunohistochemistry and western blot. The correlation between ARL2 expression and the outcomes of glioma patients was evaluated with survival data from TCGA, CGGA and Rembrandt dat

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5975491 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature