Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

ABSTRACT:

Background

The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while conclusions regarding tissue-specificity are typically based on small number of samples, tissues and CpGs. Here, we systematically investigate the tissue-specific character of age-related DNA methylation changes at the level of the CpG, functional genomic region and nearest gene in a large dataset.

Results

We assembled a compendium of public data, encompassing genome-wide DNA methylation data (Illumina 450k array) on 8092 samples from 16 different tissues, including 7 tissues with moderate to high sample numbers (Dataset size range 96-1202, N_total = 2858). In the 7 tissues (brain, buccal, liver,

SUBMITTER: Slieker RC 

PROVIDER: S-EPMC5975493 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature