Clinical and genetic characteristics of pulmonary arterial hypertension in Lebanon.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a rare disease with an incidence rate of 2-6 cases per million per year. Our knowledge of the disease in the Middle East and North Africa (MENA) region is limited by the small number of clinical studies and the complete absence of genetic studies.

Methods

Our aim was to shed light on the clinical and genetic characteristics of PAH in Lebanon and the region by using exome sequencing on PAH patients referred to the American University of Beirut Medical Center (AUBMC). Twenty-one idiopathic, hereditary and Congenital Heart Disease (CHD) PAH patients were prospectively recruited, their clinical data summarized, and sequencing performed.

Results

The mean age at diagnosis was 33 years with a female preponderance of 70%. Th

SUBMITTER: Abou Hassan OK 

PROVIDER: S-EPMC5975525 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature