Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.

ABSTRACT:

Background

Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations. Sulforaphane, a supplement with indirect antioxidant effects that are derived from broccoli sprouts and seeds, was recently shown to lead to improvements in behavior and social responsiveness in children with ASD. We conducted the current open-label study to determine if we could identify changes in urinary metabolites that were associated with clinical improvements with the goal of identifying a potential mechanism of action.

Methods

Children and young adults enrolled in a school for children with ASD and related neurodevelopmental disorders were recru

SUBMITTER: Bent S 

PROVIDER: S-EPMC5975568 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature