An integrated analysis of key microRNAs, regulatory pathways and clinical relevance in bladder cancer.

ABSTRACT:

Objective

The aim of this study was to identify the key microRNAs (miRNAs) and their regulatory networks in bladder cancer (BC).

Materials and methods

Three miRNA and three gene expression microarray datasets were downloaded for analysis from Gene Expression Omnibus database. The differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs) were accessed by the use of GEO2R. Gene ontology process and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed by using the Database for Annotation, Visualization and Integrated Discovery program. Protein-protein interaction (PPI) and miRNA-mRNA regulatory networks were established by using the Search Tool for the Retrieval of Interacting Genes/Proteins and Cytoscape tool. Besides, the r

SUBMITTER: Li D 

PROVIDER: S-EPMC5975595 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature