Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.

ABSTRACT:

Background

Multiple lines of evidence indicate that aspirin has an antineoplastic effect in the large bowel. Randomized clinical trials have been conducted to evaluate the effectiveness of aspirin for reducing the risk of colorectal adenomas. A meta-analysis of these trials will provide more precise estimates of the aspirin effect, both overall and in subgroups.

Methods

We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas. We used random-effects meta-analysis to estimate risk ratios and 95% confidence intervals (CIs) for the effect of aspirin on the occurrence of adenomas and of advanced lesions (ie, tubulovillous adenomas, villous adenomas, adenomas >or=1 cm in diameter, adenomas with hi

SUBMITTER: Cole BF 

PROVIDER: S-EPMC5975663 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature