Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z.

ABSTRACT:

Background

Actinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess the metabolic capabilities of this microorganism under producing conditions.

Results

The model, iBP722, was reconstructed based on the functional reannotation of the complete genome sequence of A. succinogenes 130Z and manual inspection of metabolic pathways, covering 1072 enzymatic reactions associated with 722 metabolic genes that involve 713 metabolites. The highly curated model was effective in capturing the growth of A. succinogenes on various carbon sources, as well as the SA production under various growth conditions with fair agreement between expe

SUBMITTER: Pereira B 

PROVIDER: S-EPMC5975692 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature