"Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit.

ABSTRACT: Retinal direction-selective ganglion cells (DSGCs) have the remarkable ability to encode motion over a wide range of contrasts, relying on well-coordinated excitation and inhibition (E/I). E/I is orchestrated by a diverse set of glutamatergic bipolar cells that drive DSGCs directly, as well as indirectly through feedforward GABAergic/cholinergic signals mediated by starburst amacrine cells. Determining how direction-selective responses are generated across varied stimulus conditions requires understanding how glutamate, acetylcholine, and GABA signals are precisely coordinated. Here, we use a combination of paired patch-clamp recordings, serial EM, and large-scale multi-electrode array recordings to show that a single high-sensitivity source of glutamate is processed differentially by star

SUBMITTER: Sethuramanujam S 

PROVIDER: S-EPMC5975974 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature