Gene expression to mitochondrial metabolism: Variability among cultured Trypanosoma cruzi strains.

ABSTRACT: The insect-transmitted protozoan parasite Trypanosoma cruzi experiences changes in nutrient availability and rate of flux through different metabolic pathways across its life cycle. The species encompasses much genetic diversity of both the nuclear and mitochondrial genomes among isolated strains. The genetic or expression variation of both genomes are likely to impact metabolic responses to environmental stimuli, and even steady state metabolic function, among strains. To begin formal characterization these differences, we compared aspects of metabolism between genetically similar strains CL Brener and Tulahuen with less similar Esmeraldo and Sylvio X10 strains in a culture environment. Epimastigotes of all strains took up glucose at similar rates. However, the degree of medium acidificat

SUBMITTER: Kalem MC 

PROVIDER: S-EPMC5976161 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature