The MR-Base platform supports systematic causal inference across the human phenome.

ABSTRACT: Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base (http://www.mrbase.org): a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR. The software includes several sensitivity analyses for assessing the impact o

SUBMITTER: Hemani G 

PROVIDER: S-EPMC5976434 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature