Survival outcomes of patients with germ cell tumors treated with high-dose chemotherapy for refractory or relapsing disease.

ABSTRACT:

Introduction

Male patients with metastatic germ cell tumors can be cured in up to 96% of cases depending on stage and IGCCCG prognosis group. Treatment in relapse consists of conventional or high-dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) combined with local treatment modalities.

Results

Most patients were classified as poor risk according to IGCCCG (n = 24; 52%) and as intermediate (n = 12), high (n = 16), or very high risk (n = 9) at time of first relapse according to IPFSG criteria. In 67% of patients (n = 31) HDCT/ASCT was performed as first salvage treatment in relapse or for primary refractory disease following first line chemotherapy. In 46% of patients (n = 21) progressive disease was documented

SUBMITTER: Zschabitz S 

PROVIDER: S-EPMC5976483 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature