Leptin receptor q223r polymorphism influences neutrophil mobilization after Clostridium difficile infection.

ABSTRACT: Clostridium difficile is the leading cause of nosocomial infections in the United States. Clinical disease outcomes after C. difficile infection (CDI) are dependent on intensity of host inflammatory responses. Specifically, peak peripheral white blood cell (WBC) count >20 × 10⁹ l^-1 is an indicator of adverse outcomes in CDI patients, and is associated with higher 30-day mortality. We show that homozygosity for a common single nucleotide polymorphism (Q to R mutation in leptin receptor that is present in up to 50% of people), significantly increases the risk of having peak peripheral WBC count >20 × 10⁹ l^-1 (odds ratio=5.41; P=0.0023) in CDI patients. In a murine model of CDI, we demonstrate that mice homozygous for the same single nucleotide poly

SUBMITTER: Jose S 

PROVIDER: S-EPMC5976520 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature