Ontology highlight
ABSTRACT:
SUBMITTER: Eriksson D
PROVIDER: S-EPMC5976627 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Scientific reports 20180530 1
Autoimmune Addison's disease (AAD) is the predominating cause of primary adrenal failure. Despite its high heritability, the rarity of disease has long made candidate-gene studies the only feasible methodology for genetic studies. Here we conducted a comprehensive reinvestigation of suggested AAD risk loci and more than 1800 candidate genes with associated regulatory elements in 479 patients with AAD and 2394 controls. Our analysis enabled us to replicate many risk variants, but several other pr ...[more]