Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration.

ABSTRACT: Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric muscle loss (VML). Therapeutic approaches involving acellular matrices represent an emerging and promising strategy to promote regeneration of skeletal muscle following injury. Here we investigated the ability of three different decellularised skeletal muscle scaffolds to support muscle regeneration in a xenogeneic immune-competent model of VML, in which the EDL muscle was surgically resected. All implanted acellular matrices, used to replace the resected muscles, were able to generate functional artificial muscles by promoting host myogenic cell migration and differentiation, as well as nervous fibres, vascular networks, and satellite cell (SC) homing. However, acellular tissue mainly composed o

SUBMITTER: Urciuolo A 

PROVIDER: S-EPMC5976677 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature