Clinicopathological Features and Prognosis of Primary GISTs with Tumor Rupture in the Real World.

ABSTRACT:

Background

Patients with ruptured gastrointestinal stromal tumor (GIST) are recommended for imatinib adjuvant therapy; however, their clinicopathological features and prognosis in the era of imatinib are unknown.

Patients and methods

The study cohort included 665 patients with histologically proven primary GISTs who underwent R0 or R1 surgery between 2003 and 2007; the validation cohort included 182 patients between 2000 and 2014. The definitions of tumor rupture in the study included perforation at tumor site, tumor fracture, piecemeal resection including open biopsy, and macroscopic injuries to the pseudocapsule.

Results

Tumor rupture occurred in 21 (3.2%) of 665 and 5 (2.9%) of 182 patients in the study and validation cohort, respectively. Ruptured GISTs were more

SUBMITTER: Nishida T 

PROVIDER: S-EPMC5976711 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature