Abrupt Decline in Kidney Function Precipitating Initiation of Chronic Renal Replacement Therapy.

ABSTRACT:

Introduction

Abrupt declines in kidney function often occur in patients with advanced chronic kidney disease and may exacerbate the need to initiate dialysis treatment. It is unclear how frequently such events occur in patients transitioning to chronic dialysis therapy, and what outcomes they are associated with.

Methods

We examined a national cohort of 23,349 US veterans with incident end-stage renal disease (ESRD) and with available pre-ESRD estimated glomerular filtration rate (eGFR) to identify abrupt declines in kidney function, defined as an unexpected >50% decrease in eGFR at the time of chronic dialysis transition. Associations with all-cause mortality and with renal recovery were examined in Cox proportional hazard and competing risk regression models.

Results

SUBMITTER: Kovesdy CP 

PROVIDER: S-EPMC5976817 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature