Association Between Newborn Metabolic Profiles and Pediatric Kidney Disease.

ABSTRACT:

Introduction

Metabolomics offers considerable promise in early disease detection. We set out to test the hypothesis that routine newborn metabolic profiles at birth, obtained through screening for inborn errors of metabolism, would be associated with kidney disease and add incremental information to known clinical risk factors.

Methods

We conducted a population-level cohort study in Ontario, Canada, using metabolic profiles from 1,288,905 newborns from 2006 to 2015. The primary outcome was chronic kidney disease (CKD) or dialysis. Individual metabolites and their ratio combinations were examined by logistic regression after adjustment for established risk factors for kidney disease and incremental risk prediction measured.

Results

CKD occurred in 2086 (0.16%, median t

SUBMITTER: Sood MM 

PROVIDER: S-EPMC5976820 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature