Bioavailable Testosterone Is Positively Associated With Bone Mineral Density in Male Kidney Transplantation Candidates.

ABSTRACT:

Introduction

Low levels of sex hormones are common in patients with chronic kidney disease (CKD) and may be a contributing factor to bone fragility. We investigated associations between levels of sex hormones and bone mineral density (BMD) in adult kidney transplantation candidates.

Methods

Volumetric BMD of spine and hip were measured by computed tomography. Parathyroid hormone (PTH), testosterone (T), estradiol (E), and sex hormone-binding globulin were measured from fasting morning blood samples. Bioavailable (Bio) T and E were calculated based on constants for protein binding.

Results

A total of 146 patients (102 men and 44 women) were included in the analyses. The median age was 54 years (range, 32-72 years); 32% were diabetic; and 36% received maintenance dialys

SUBMITTER: Jorgensen HS 

PROVIDER: S-EPMC5976823 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature