Risk Factors for Prognosis in Patients With Severely Decreased GFR.

ABSTRACT:

Introduction

Patients with chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR) <30 ml/min per 1.73 m² (corresponding to CKD stage G4+) comprise a minority of the overall CKD population but have the highest risk for adverse outcomes. Many CKD G4+ patients are older with multiple comorbidities, which may distort associations between risk factors and clinical outcomes.

Methods

We undertook a meta-analysis of risk factors for kidney failure treated with kidney replacement therapy (KRT), cardiovascular disease (CVD) events, and death in participants with CKD G4+ from 28 cohorts (n = 185,024) across the world who were part of the CKD Prognosis Consortium.

Results

In the fully adjusted meta-analysis, risk factors associated with KRT

SUBMITTER: Evans M 

PROVIDER: S-EPMC5976849 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature