Transcription Factor Binding Site Enrichment Analysis in Co-Expression Modules in Celiac Disease.

ABSTRACT: The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression observed in celiac disease (CD). Differential co-expression modules were identified in the acute and chronic responses to gliadin using expression data from a previous microarray study in duodenal biopsies. Transcription factor binding site (TFBS) and Gene Ontology (GO) annotation enrichment analyses were performed in differentially co-expressed genes (DCGs) and selection of candidate regulators was performed. Expression of candidates was measured in clinical samples and the activation of the TFs was further characterized in C2BBe1 cells upon gliadin challenge. Enrichment anal

SUBMITTER: Romero-Garmendia I 

PROVIDER: S-EPMC5977185 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature