Within-Host Recombination in the Foot-and-Mouth Disease Virus Genome.

ABSTRACT: Recombination is one of the determinants of genetic diversity in the foot-and-mouth disease virus (FMDV). FMDV sequences have a mosaic structure caused by extensive intra- and inter-serotype recombination, with the exception of the capsid-encoding region. While these genome-wide patterns of broad-scale recombination are well studied, not much is known about the patterns of recombination that may exist within infected hosts. In addition, detection of recombination among viruses evolving at the within-host level is challenging due to the similarity of the sequences and the limitations in differentiating recombination from point mutations. Here, we present the first analysis of recombination events between closely related FMDV sequences occurring within buffalo hosts. The detection of these e

SUBMITTER: Ferretti L 

PROVIDER: S-EPMC5977214 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature