Characterization of Nanoparticle Batch-To-Batch Variability.

ABSTRACT: A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nan

SUBMITTER: Mulhopt S 

PROVIDER: S-EPMC5977325 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature