Proton-pump inhibitors among adults: a nationwide drug-utilization study.

ABSTRACT:

Background

The use of proton-pump inhibitors (PPIs) has grown worldwide, and there are concerns about increased unsubstantiated long-term use. The aim of the study was to describe the real-world use of PPIs over the past decade in an entire national population.

Methods

This was a nationwide population-based drug-utilization study. Patterns of outpatient PPI use among adults in Iceland between 2003 and 2015 were investigated, including annual incidence and prevalence, duration of use, and dose of tablet used (lower versus higher), as well as the proportion of PPI use attributable to gastroprotection.

Results

We observed 1,372,790 prescription fills over the entire study period, of which 95% were for higher-dose PPIs. Annual incidence remained stable across time

SUBMITTER: Halfdanarson OO 

PROVIDER: S-EPMC5977421 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature