Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disease heritability and additional risk variants have yet to be identified. Here we performed a GWAS followed by a meta-analysis to identify new genome-wide significant loci for SLE.

Methods

We genotyped a cohort of 907 patients with SLE (cases) and 1524 healthy controls from Spain and performed imputation using the 1000 Genomes reference data. We tested for association using logistic regression with correction for the principal components of variation. Meta-analys

SUBMITTER: Julia A 

PROVIDER: S-EPMC5977506 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature