Dataset Information

Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging.

ABSTRACT:

Background

Operative management of pancreatic ductal adenocarcinoma (PDAC) is complicated by several key decisions during the procedure. Identification of metastatic disease at the outset and, when none is found, complete (R0) resection of primary tumor are key to optimizing clinical outcomes. The use of tumor-targeted molecular imaging, based on photoacoustic and fluorescence optical imaging, can provide crucial information to the surgeon. The first-in-human use of multimodality molecular imaging for intraoperative detection of pancreatic cancer is reported using cetuximab-IRDye800, a near-infrared fluorescent agent that binds to epidermal growth factor receptor.

Methods

A dose-escalation study was performed to assess safety and feasibility of targeting and identifying PDAC in a tumor-specific manner using cetuximab-IRDye800 in patients undergoing surgical resection for pancreatic cancer. Patients received a loading dose of 100 mg of unlabeled cetuximab before infusion of cetuximab-IRDye800 (50 mg or 100 mg). Multi-instrument fluorescence imaging was performed throughout the surgery in addition to fluorescence and photoacoustic imaging ex vivo.

Results

Seven patients with resectable pancreatic masses suspected to be PDAC were enrolled in this study. Fluorescence imaging successfully identified tumor with a significantly higher mean fluorescence intensity in the tumor (0.09 ± 0.06) versus surrounding normal pancreatic tissue (0.02 ± 0.01), and pancreatitis (0.04 ± 0.01; p < 0.001), with a sensitivity of 96.1% and specificity of 67.0%. The mean photoacoustic signal in the tumor site was 3.7-fold higher than surrounding tissue.

Conclusions

The safety and feasibilty of intraoperative, tumor-specific detection of PDAC using cetuximab-IRDye800 with multimodal molecular imaging of the primary tumor and metastases was demonstrated.

SUBMITTER: Tummers WS

PROVIDER: S-EPMC5977989 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging.

Tummers Willemieke S WS Miller Sarah E SE Teraphongphom Nutte T NT Gomez Adam A Steinberg Idan I Huland David M DM Hong Steve S Kothapalli Sri-Rajasekhar SR Hasan Alifia A Ertsey Robert R Bonsing Bert A BA Vahrmeijer Alexander L AL Swijnenburg Rutger-Jan RJ Longacre Teri A TA Fisher George A GA Gambhir Sanjiv S SS Poultsides George A GA Rosenthal Eben L EL

Annals of surgical oncology 20180417 7

<h4>Background</h4>Operative management of pancreatic ductal adenocarcinoma (PDAC) is complicated by several key decisions during the procedure. Identification of metastatic disease at the outset and, when none is found, complete (R0) resection of primary tumor are key to optimizing clinical outcomes. The use of tumor-targeted molecular imaging, based on photoacoustic and fluorescence optical imaging, can provide crucial information to the surgeon. The first-in-human use of multimodality molecul ...[more]

PMID: 29667116

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Dataset Information

Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging.

Background

Methods

Results

Conclusions

Publications

Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging.

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