Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging.

ABSTRACT:

Background

Operative management of pancreatic ductal adenocarcinoma (PDAC) is complicated by several key decisions during the procedure. Identification of metastatic disease at the outset and, when none is found, complete (R0) resection of primary tumor are key to optimizing clinical outcomes. The use of tumor-targeted molecular imaging, based on photoacoustic and fluorescence optical imaging, can provide crucial information to the surgeon. The first-in-human use of multimodality molecular imaging for intraoperative detection of pancreatic cancer is reported using cetuximab-IRDye800, a near-infrared fluorescent agent that binds to epidermal growth factor receptor.

Methods

A dose-escalation study was performed to assess safety and feasibility of targeting and identifying PDAC

SUBMITTER: Tummers WS 

PROVIDER: S-EPMC5977989 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature