Lung cancer in never smokers from the Princess Margaret Cancer Centre.

ABSTRACT:

Introduction

Lung cancer in never smokers represents a distinct epidemiological, clinical, and molecular entity.

Results

Most 712 never smoking lung cancer patients were female (72%) with a median age at diagnosis of 62.2 years (18-94). Caucasians (46%), East Asians (42%), adenocarcinoma histology (87%) and presentation with metastatic disease at diagnosis (59%) were common. Of 515 patients with available archival tissue, the most common identified single mutations were EGFR (52.2%), followed by ALK (7.5%), KRAS (2.3%), TP53 (1.3%), ERBB2 (1%), BRAF (0.4%), PIK3CA (0.4%), SMAD4 (0.4%), CTNNB1 (0.2%), AKT1 (0.2%), and NRAS (0.2%); 8% tumors had multiple mutations, while 25.8% had none identified. Med

SUBMITTER: Korpanty GJ 

PROVIDER: S-EPMC5978248 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature