Fabrication of Multifaceted Micropatterned Surfaces with Laser Scanning Lithography.

ABSTRACT: The implementation of engineered surfaces presenting micrometer-sized patterns of cell adhesive ligands against a biologically inert background has led to numerous discoveries in fundamental cell biology. While existing surface patterning strategies allow for pattering of a single ligand it is still challenging to fabricate surfaces displaying multiple patterned ligands. To address this issue we implemented Laser Scanning Lithography (LSL), a laser-based thermal desorption technique, to fabricate multifaceted, micropatterned surfaces that display independent arrays of subcellular-sized patterns of multiple adhesive ligands with each ligand confined to its own array. We demonstrate that LSL is a highly versatile "maskless" surface patterning strategy that provides the ability to create patt

SUBMITTER: Slater JH 

PROVIDER: S-EPMC5978433 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature