Plasma Biomarker Enrichment of Clinical Prognostic Indices in Malignant Pleural Mesothelioma.

ABSTRACT:

Objectives

Prognostic models for malignant pleural mesothelioma (MPM) are needed to prevent potentially futile outcomes. We combined MPM plasma biomarkers with validated clinical prognostic indices to determine whether stratification of risk for death in 194 patients with MPM improved.

Methods

Individuals were recruited from three different centers: a discovery cohort (83 patients with MPM) created by combining patients from two U.S. centers and a separate, independent cohort from Canada (111 patients with MPM). Univariable and multivariable analyses were performed on the initial discovery and independent cohorts separately. In the multivariable analyses, prognostic factors were adjusted for the European Organisation for Research and Treatment of Cancer (EORTC) prognostic in

SUBMITTER: Pass HI 

PROVIDER: S-EPMC5978729 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature