Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study.

ABSTRACT:

Objectives

Smoking is associated with an increased risk of psoriatic arthritis (PsA) in the general population, but not among patients with psoriasis. We sought to clarify the possible methodological mechanisms behind this paradox.

Methods

Using 1995-2015 data from The Health Improvement Network, we performed survival analysis to examine the association between smoking and incident PsA in the general population and among patients with psoriasis. We clarified the paradox using mediation analysis and conducted bias sensitivity analyses to evaluate the potential impact of index event bias and quantify its magnitude from uncontrolled/unmeasured confounders.

Results

Of 6.65 million subjects without PsA at baseline, 225 213 participants had psoriasis and 7057 developed inci

SUBMITTER: Nguyen UDT 

PROVIDER: S-EPMC5978759 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature