Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation.

ABSTRACT: Markers of inflammation, including plasma C-reactive protein (CRP), are associated with an increased risk of cardiovascular disease, and it has been suggested that this association is causal. However, the relationship between inflammation and cardiovascular disease has not been extensively studied in patients with chronic kidney disease. To evaluate this, we used data from the Study of Heart and Renal Protection (SHARP) to assess associations between circulating CRP and LDL cholesterol levels and the risk of vascular and non-vascular outcomes. Major vascular events were defined as nonfatal myocardial infarction, cardiac death, stroke or arterial revascularization, with an expanded outcome of vascular events of any type. Higher baseline CRP was associated with an increased risk of major vas

SUBMITTER: Storey BC 

PROVIDER: S-EPMC5978933 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature