Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal α7 nACh receptors in mice.

ABSTRACT:

Background and purpose

Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear. We investigated, in a mouse model, the effect of exercise intensity during chronic nicotine exposure on nicotine withdrawal severity, binding of α4β2*, α7 nicotinic acetylcholine (nAChR), μ-opioid (μ receptors) and D₂ dopamine receptors and on brain-derived neurotrophic factor (BDNF) and plasma corticosterone levels.

Experimental approach

Male C57Bl/6J mice treated with nicotine (minipump, 24 mg·kg^-1 ·day^-1 ) or saline for 14 days underwent one of three concurrent exercise regimes: 24, 2 or 0 h·day^-1 voluntary wheel running. Mecamylamine-precipitated withdrawal symptoms

SUBMITTER: Keyworth H 

PROVIDER: S-EPMC5978981 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature