Linkage mapping of yeast cross protection connects gene expression variation to a higher-order organismal trait.

ABSTRACT: Gene expression variation is extensive in nature, and is hypothesized to play a major role in shaping phenotypic diversity. However, connecting differences in gene expression across individuals to higher-order organismal traits is not trivial. In many cases, gene expression variation may be evolutionarily neutral, and in other cases expression variation may only affect phenotype under specific conditions. To understand connections between gene expression variation and stress defense phenotypes, we have been leveraging extensive natural variation in the gene expression response to acute ethanol in laboratory and wild Saccharomyces cerevisiae strains. Previous work found that the genetic architecture underlying these expression differences included dozens of "hotspot" loci that affected many

SUBMITTER: Stuecker TN 

PROVIDER: S-EPMC5978988 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature