Radiation-Induced Gene Expression Changes in High and Low Grade Breast Cancer Cell Types.

ABSTRACT:

Background

There is extensive scientific evidence that radiation therapy (RT) is a crucial treatment, either alone or in combination with other treatment modalities, for many types of cancer, including breast cancer (BC). BC is a heterogeneous disease at both clinical and molecular levels, presenting distinct subtypes linked to the hormone receptor (HR) status and associated with different clinical outcomes. The aim of this study was to assess the molecular changes induced by high doses of ionizing radiation (IR) on immortalized and primary BC cell lines grouped according to Human epidermal growth factor receptor (HER2), estrogen, and progesterone receptors, to study how HR status influences the radiation response. Our genomic approach using in vitro and ex-vivo models (e.g., prima

SUBMITTER: Bravata V 

PROVIDER: S-EPMC5979377 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature