Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications.

ABSTRACT: Recent evidence from studies suggests that aged black garlic also has an effect on health. The major aim of the present study is to compare the effect of raw and aged black garlic on postischemic cardiac recovery. Male Sprague Dawley rats were randomly divided into three groups. Animals of the first group were fed with raw garlic, animals of the second group received aged black garlic, while the third group served as vehicle-treated controls. Upon conclusion of the treatment, isolated hearts were undertaken to ischemia/reperfusion. Heart function and infarct size were measured and the level of HO-1 and iNOS were studied. Superior postischemic cardiac function and reduced infarct size in both garlic treated groups compared to the drug-free control group, indicated cardioprotective effects.

SUBMITTER: Czompa A 

PROVIDER: S-EPMC5979444 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature