Regulation of Bicarbonate Secretion in Marine Fish Intestine by the Calcium-Sensing Receptor.

ABSTRACT: In marine fish, high epithelial intestinal HCO₃⁻ secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis. The present study was designed to expose the putative role for calcium and the calcium-sensing receptor (CaSR) in the regulation of HCO₃⁻ secretion in the intestine of the sea bream (Sparus aurata L.). Effects on the expression of the CaSR in the intestine were evaluated by qPCR and an increase was observed in the anterior intestine in fed fish compared with unfed fish and with different regions of intestine. CaSR expression reflected intestinal fluid calcium concentration. In addition, anterior intestine tissue was mounted in Ussing chambers to test the putative regulation of HCO₃

SUBMITTER: Gregorio SF 

PROVIDER: S-EPMC5979614 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature