Three-dimensional Epigenome Statistical Model: Genome-wide Chromatin Looping Prediction.

ABSTRACT: This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcription factor profiles using the statistical learning. The predictions obtained by 3DEpiLoop are highly consistent with the reported experimental interactions. The complex signatures of epigenomic and transcription factors within the physically interacting chromatin regions (anchors) are similar across all genomic scales: genomic domains, chromosomal territories, cell types, and different individuals. We report the most important epigenetic and transcription factor features used fo

SUBMITTER: Al Bkhetan Z 

PROVIDER: S-EPMC5979957 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature