A micro-CT-based method for quantitative brain lesion characterization and electrode localization.

ABSTRACT: Lesion verification and quantification is traditionally done via histological examination of sectioned brains, a time-consuming process that relies heavily on manual estimation. Such methods are particularly problematic in posterior cortical regions (e.g. visual cortex), where sectioning leads to significant damage and distortion of tissue. Even more challenging is the post hoc localization of micro-electrodes, which relies on the same techniques, suffers from similar drawbacks and requires even higher precision. Here, we propose a new, simple method for quantitative lesion characterization and electrode localization that is less labor-intensive and yields more detailed results than conventional methods. We leverage staining techniques standard in electron microscopy with the use of commod

SUBMITTER: Masis J 

PROVIDER: S-EPMC5980003 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature