Furin inhibitor protects against neuronal cell death induced by activated NMDA receptors.

ABSTRACT: The proprotein convertases (PCs) act as serine proteases and are known to convert diverse precursor proteins into their active forms. Among the PCs, furin has been considered to play a crucial role not only in embryogenesis, but also in the initiation and progression of certain pathologic conditions. However, the roles played by furin with respect to neuronal cell injuries remain to be determined. An excessive influx of Ca²⁺ through the N-methyl-d-aspartate (NMDA) receptor has been associated with diverse neurological and neurodegenerative disorders. The aim of this study was to achieve further insight into the pathophysiologic roles of furin in cultured cortical neurons. We demonstrated that furin inhibitors dose-dependently prevented neuronal injury induced by NMDA treatment.

SUBMITTER: Yamada M 

PROVIDER: S-EPMC5980093 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature