Self-Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma.

ABSTRACT: Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small-molecule therapeutics exhibit low efficacies and severe side effects in the clinic. Drug-delivery platforms based on nanotechnology, particularly for self-stabilized delivery platforms with prolonged blood circulation, enhanced intratumoral accumulation, improved antitumor efficacy, and diminished side effects, may break the deadlock on osteosarcoma chemotherapy. Here, a cisplatin (CDDP)-crosslinked hyaluronic acid (HA) nanogel (CDDPHANG) is prepared for effective delivery of doxorubicin (DOX) to treat osteosarcoma. Importantly, both DOX and CDDP have led clinically

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5980114 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature