Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.

ABSTRACT:

Aims

This study aimed to analyse the effects of genetic polymorphisms in drug transporters and metabolizing enzymes, and clinical laboratory data on the pharmacokinetic parameters of apixaban.

Methods

Data were collected from 81 Japanese patients with atrial fibrillation. Pharmacogenomic data were stratified by ABCB1, ABCG2 and CYP3A5 polymorphisms. The pharmacokinetic profile of apixaban was described by a one-compartment model with first-order absorption. Population pharmacokinetic analysis was conducted using a nonlinear mixed effect modelling (NONMEM™) program.

Results

The nonlinear relationship between oral clearance (CL/F) of apixaban and creatinine clearance (Ccr) was observed. The population mean of CL/F for a typical patient (Ccr value of 70 ml min^-1

SUBMITTER: Ueshima S 

PROVIDER: S-EPMC5980466 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature