Body fat reduction without cardiovascular changes in mice after oral treatment with the MAO inhibitor phenelzine.

ABSTRACT:

Background and purpose

Phenelzine is an antidepressant drug known to increase the risk of hypertensive crisis when dietary tyramine is not restricted. However, this MAO inhibitor inhibits other enzymes not limited to the nervous system. Here we investigated if its antiadipogenic and antilipogenic effects in cultured adipocytes could contribute to decreased body fat in vivo, without unwanted hypertensive or cardiovascular effects.

Experimental approach

Mice were fed a standard chow and given 0.028% phenelzine in drinking water for 12 weeks. Body composition was determined by NMR. Cardiovascular dysfunction was assessed by heart rate variability analyses and by evaluation of cardiac oxidative stress markers. MAO activity, hydrogen peroxide release and triacylglycerol turnover

SUBMITTER: Carpene C 

PROVIDER: S-EPMC5980542 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature