Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field.

ABSTRACT: Control of chronic pain is frequently inadequate and/or associated with intolerable adverse effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly two decades of preclinical and clinical research supports the involvement of transient receptor potential (TRP) channels in temperature perception, nociception and sensitization. Although there has been considerable excitement around the therapeutic potential of this channel family since the cloning and identification of TRPV1 cation channels as the capsaicin receptor more than 20 years ago, only modulators of a few channels have been tested clinically. TRPV1 channel antagonists have suffered from side effects related to the channel's role in temperature sensation; however, high dose formulations of capsaici

SUBMITTER: Moran MM 

PROVIDER: S-EPMC5980611 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature