Human lactoferrin attenuates the proinflammatory response of neonatal monocyte-derived macrophages.

ABSTRACT: Bioactive components of human milk, such as human lactoferrin (hLF), play an essential role in gut microbiome homeostasis and protection against neonatal inflammatory diseases. Neonatal intestinal macrophages display a proinflammatory profile that might contribute to inflammatory mucosal injury. Therefore, the aim of the study was to investigate the immunomodulatory effects of hLF on differentiation and activation of monocyte-derived macrophages (moMϕ). Monocytes isolated from umbilical cord blood of term neonates and peripheral blood of healthy adults were differentiated in the absence or presence of hLF, and differentiation, apoptosis and phagocytosis were evaluated. Cytokine production, Toll-like receptor (TLR) signalling and activation marker expression were investigated upon activatio

SUBMITTER: Wisgrill L 

PROVIDER: S-EPMC5980625 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature