Patterns of recurrence in oral tongue cancer with perineural invasion.

ABSTRACT: BACKGROUND:Although perineural invasion (PNI) is recognized as an adverse prognostic factor in oral tongue squamous cell carcinoma (SCC), the patterns of failure are poorly defined. METHODS:Patients with oral tongue SCC who received primary surgical treatment were identified. Specimens were reviewed by head and neck pathologists. Disease-specific survival (DSS) and locoregional recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant recurrence-free survival (DRFS) were calculated. The PNI and PNI characteristics were analyzed as predictors of outcome. The utility of grading the extent of PNI was assessed by quantifying the number of PNI foci per slide reviewed, nerve caliber, and percent circumference involved. RESULTS:Patients with PNI had a decreased DSS; h

SUBMITTER: Cracchiolo JR 

PROVIDER: S-EPMC5980694 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature