Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes.

ABSTRACT: Members of the transglutaminase family catalyze the formation of isopeptide bonds between a polypeptide-bound glutamine and a low molecular weight amine (e.g., spermidine) or the ɛ-amino group of a polypeptide-bound lysine. Transglutaminase 2 (TG2), a prominent member of this family, is unique because in addition to being a transamidating enzyme, it exhibits numerous other activities. As a result, TG2 plays a role in many physiological processes, and its function is highly cell type specific and relies upon a number of factors, including conformation, cellular compartment location, and local concentrations of Ca²⁺ and guanine nucleotides. TG2 is the most abundant transglutaminase in the central nervous system (CNS) and plays a pivotal role in the CNS injury response. How TG2 aff

SUBMITTER: Quinn BR 

PROVIDER: S-EPMC5980740 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature