Substrate mediated redox partner selectivity of cytochrome P450.

ABSTRACT: Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

SUBMITTER: Gentry KA 

PROVIDER: S-EPMC5980791 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature