Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization.

ABSTRACT:

Background

The pathogen Helicobacter pylori encounters many stressors as it transits to and infects the gastric epithelium. Gastric acidity is the predominate stressor encountered by the bacterium during initial infection and establishment of persistent infection. H. pylori initiates a rapid response to acid to maintain intracellular pH and proton motive force appropriate for a neutralophile. However, acid sensing by H. pylori may also serve as a transcriptional trigger to increase the levels of other pathogenic factors needed to subvert host defenses such as acid acclimation, antioxidants, flagellar synthesis and assembly, and CagA secretion.

Materials and methods

Helicobacter pylori were acid challenged at pH 3.0, 4.5, 6.0 vs nonacidic pH for 4 hours in the presence of ure

SUBMITTER: Marcus EA 

PROVIDER: S-EPMC5980792 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature