Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery.

ABSTRACT: Hexoses are the major source of energy and carbon skeletons for biosynthetic processes in all kingdoms of life. Their cellular uptake is mediated by specialized transporters, including glucose transporters (GLUT, SLC2 gene family). Malfunction or altered expression pattern of GLUTs in humans is associated with several widespread diseases including cancer, diabetes and severe metabolic disorders. Their high relevance in the medical area makes these transporters valuable drug targets and potential biomarkers. Nevertheless, the lack of a suitable high-throughput screening system has impeded the determination of compounds that would enable specific manipulation of GLUTs so far. Availability of structural data on several GLUTs enabled in silico ligand screening, though limited by the fac

SUBMITTER: Schmidl S 

PROVIDER: S-EPMC5980966 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature